Polyvinyl alcohol, commonly known as PVA, is a versatile polymer with a wide range of applications in various industries. In this article, we will explore the properties and uses of different PVA variants, including PVA 092-53, PVA 2492, KURARAY POVAL, Sinopec PVA, and PVA 55-95.

What is Polyvinyl Alcohol?

Polyvinyl alcohol is a water-soluble synthetic polymer derived from vinyl acetate. It is produced through the hydrolysis of polyvinyl acetate, resulting in the removal of acetate groups. The degree of hydrolysis determines the water solubility and other properties of the PVA.

PVA 092-53: Versatile and High-Performance

PVA 092-53 is a high-quality polyvinyl alcohol known for its excellent film-forming ability and adhesive properties. It finds applications in diverse industries, such as papermaking, textiles, construction, and packaging. Its high degree of hydrolysis ensures superior water solubility and film strength, making it an ideal choice for various applications.

PVA 2492: Water-Soluble and Environmentally Friendly

PVA 2492 is a water-soluble polymer with excellent film-forming properties, making it suitable for applications like adhesives, coatings, and textile processing. It possesses exceptional tensile strength, flexibility, and transparency, enabling it to improve the performance and durability of products. Moreover, PVA 2492 is biodegradable, making it an environmentally friendly choice.

KURARAY POVAL: Leading PVA Brand

KURARAY POVAL is a well-known and trusted brand in the PVA industry. Its range of PVA products offers exceptional quality and performance. KURARAY POVAL ensures consistent product properties, such as excellent tensile strength, adhesion, and film-forming capabilities. The brand’s dedication to innovation and sustainability has made it a preferred choice for various applications.

Sinopec PVA: Reliable and Diverse Applications

Sinopec PVA is a highly reliable PVA variant widely used in industries such as adhesives, coatings, and textile processing. It offers exceptional film-forming properties, adhesion, and tensile strength. Sinopec PVA caters to a broad range of applications due to its versatility, making it a preferred choice for manufacturers worldwide.

PVA 55-95: Well-Suited for Papermaking

PVA 55-95 is specifically designed for the papermaking industry. It enhances the paper’s strength, improves surface smoothness, and provides excellent retention and drainage properties. The use of PVA 55-95 in papermaking results in high-quality paper with improved printability and ink absorption, meeting the demands of the industry.

In conclusion, polyvinyl alcohol and its various forms, including PVA 092-53, PVA 2492, KURARAY POVAL, Sinopec PVA, and PVA 55-95, offer a wide range of applications and benefits. These PVA variants provide unique properties, such as excellent film-forming ability, adhesion, water solubility, and environmental friendliness. Manufacturers and industries across the globe rely on these high-performance PVA variants for their diverse needs.

Polyvinyl Alcohol (PVOH) is a versatile polymer known for its exceptional adhesive properties, making it a valuable ingredient in various industries. In this blog post, we will explore the manufacturing process of Polyvinyl Alcohol 1799 and highlight some important variations like PVA 100-27, PVA 1799, KURARAY POVAL, Sinopec PVA, Poval 117, PVA 117, Celvol 325, CCP BF 17, and GOHSENOL NH-18. So, let’s dive in and discover the wonders of PVOH!

Understanding Polyvinyl Alcohol 1799 and Its Applications

Polyvinyl Alcohol 1799, a specific variety of PVOH, is widely acknowledged for its outstanding film-forming ability, adhesion, and barrier properties. Featuring excellent chemical resistance and low toxicity, it is commonly used in a range of industries including:

1. Paper and Packaging: Due to its film-forming characteristics and water solubility, Polyvinyl Alcohol 1799 serves as an essential binding agent for paper coatings, textile stiffening, and packaging films.

2. Adhesives and Binders: PVOH’s adhesive properties make it valuable in manufacturing wood glues, vinyl substrates, and wallboard adhesives. Moreover, it acts as a binder in the production of coatings, ceramics, and composites.

3. Textile and Construction: PVOH serves as a warp sizing agent, emulsifier, and dispersant in textile processing, enhancing the strength and durability of fabrics. Additionally, it aids in cement modification and as a protective coating for construction materials.

4. Personal Care and Hygiene: Cosmetics, detergents, and personal care products utilize PVOH for its emulsifying and thickening properties. It enables enhanced product stability and improved texture.

Notable Varieties and Their Distinct Features

Polyvinyl Alcohol extends beyond its 1799 variant, with various other PVOH types offering specific characteristics catered to different applications. Here are some notable variations:

1. PVA 100-27: This type of PVOH offers excellent film-forming ability and tensile strength, making it ideal for applications in paper coatings, adhesives, and textile processing.

2. KURARAY POVAL: Renowned for its exceptional solubility, KURARAY POVAL is widely used in the textile industry, ensuring excellent adhesion and yarn lubrication during warp sizing.

3. Sinopec PVA: Offering outstanding viscosity and adhesive properties, Sinopec PVA finds applications in coatings, adhesives, and sealants, effectively enhancing product performance and durability.

4. Poval 117: With superior tensile strength and excellent film-forming characteristics, Poval 117 is commonly employed in the production of cement modifiers, coatings, and paper manufacturing.

5. GOHSENOL NH-18: This PVOH variant boasts exceptional water solubility, making it highly suitable for applications such as film coatings, adhesives, and detergent manufacturing.

Manufacturing Process and Quality Assurance

The production of Polyvinyl Alcohol involves several steps, starting with the hydrolysis of polyvinyl acetate. The resulting polyvinyl alcohol is then purified and processed into various types of PVOH. Manufacturers like CCP BF 17 ensure strict adherence to quality control measures, guaranteeing consistent and reliable PVOH products.

Final Thoughts

Polyvinyl Alcohol 1799 and its different variations serve as valuable components in numerous industries. From adhesives and binders to textiles and personal care products, PVOH offers remarkable properties that enhance the performance and durability of the end products. Manufacturers like Celvol 325 play a significant role in producing high-quality PVOH to meet diverse industry needs. So whether you’re involved in papermaking, construction, or personal care, PVOH can be your go-to solution for superior results.

Polyvinyl alcohol (PVOH) is a versatile polymer commonly used in a wide range of industries, from adhesives and textiles to packaging and pharmaceuticals. Among the numerous variations available, PVOH 452 has emerged as a game-changer in the market. Let’s delve into the world of PVOH 452, learn about its manufacturer, and explore its modified counterpart, Modified PVA 452, and the benefits of using POVAL.

1. What is PVOH 452 and how is it different from other PVOH variants?

PVOH 452 is a specific grade of polyvinyl alcohol that offers exceptional properties compared to other PVOH variants. It is produced through a meticulous manufacturing process, resulting in a high-quality product with excellent film-forming, emulsifying, and barrier properties. These unique attributes make PVOH 452 highly sought after in numerous industries.

2. Who is the manufacturer of PVOH 452?

PVOH 452 is proudly manufactured by a renowned company known for its expertise in the field of polymer manufacturing. With years of experience and a commitment to innovation, this manufacturer has established itself as a trusted provider of high-quality PVOH products.

3. Introducing Modified PVA 452: Enhancing Performance and Flexibility

Modified PVA 452 takes the already impressive features of PVOH 452 and enhances them further. This modified version offers increased chemical resistance, improved tensile strength, and enhanced elasticity, allowing it to excel in demanding applications. The unique modification process provides a tailored solution that meets the specific needs of various industries.

4. Discover the Advantages of Using POVAL

POVAL, also known as polyvinyl alcohol or PVOH, is a water-soluble polymer derived from PVOH 452. It is widely regarded for its exceptional film-forming properties, making it an ideal ingredient in the production of coatings, adhesives, and films. Additionally, POVAL offers excellent tensile strength, elongation, and gas barrier properties, making it highly valuable in packaging applications.

In conclusion

The introduction of PVOH 452 has revolutionized the world of PVOH manufacturing. With its exceptional properties and versatile applications, PVOH 452 has become the preferred choice for various industries. Furthermore, the modified version, Modified PVA 452, and its derivative, POVAL, offer even greater benefits, catering to specific industry needs.

As the demand for high-quality polymers continues to grow, PVOH 452 and its derivatives prove to be invaluable resources for innovative and sustainable solutions. Whether it’s enhancing product performance, improving packaging efficiency, or enhancing film-forming capabilities, PVOH 452 and its related products are setting new standards in the industry, paving the way for a more advanced and adaptable future.

Polyvinyl alcohol (PVA) is a versatile chemical compound widely used in various industries. Known for its excellent film-forming properties, PVA finds applications in adhesives, textiles, coatings, and more. In this article, we will delve into two popular variants of PVA: PVA 088-07 and PVA 0888, highlighting their features, manufacturing sources, and top suppliers.

PVA 088-07: A High-Quality PVA Grade

PVA 088-07 is a premium-quality grade of polyvinyl alcohol that offers exceptional tensile strength and adhesive properties. Manufactured by renowned companies like Kuraray, it is widely used in the textile industry for warp sizing, as it enhances the strength and flexibility of fabrics. PVA 088-07 also finds applications in paper coatings, construction materials, and emulsion polymerization.

PVA 0888: The Reliable Choice

Another widely used variant, PVA 0888, is known for its high viscosity and film-forming capabilities. With its excellent tensile strength and solubility in water, PVA 0888 is extensively used in adhesive formulations, paper coatings, and as a binder in ceramics. Renowned manufacturers like Sinopec and Mowiol produce PVA 0888 with strict quality control measures, ensuring optimal performance in various applications.

Leading PVA Manufacturers

1. Kuraray POVAL: Kuraray is a renowned manufacturer of PVA polymers, including PVA 088-07. Their commitment to innovation and quality has made them a trusted supplier worldwide. Kuraray POVAL products are known for their consistent performance and reliability.

2. Sinopec PVA: Sinopec, a major petrochemical company, produces a range of PVA grades, including PVA 0888. Sinopec PVA offers high-quality products that meet stringent industry standards and cater to the diverse needs of customers.

3. Mowiol: Mowiol 8-88, a brand of PVA 0888 produced by Clariant, is highly regarded for its exceptional film-forming properties. Mowiol products are used in various applications such as adhesives, textiles, and paper coatings, providing reliable solutions to diverse industries.

Other Notable PVA Grades

Apart from PVA 088-07 and PVA 0888, there are other noteworthy PVA grades available in the market:

• Celvol 205: Celvol, manufactured by Celanese, is a water-soluble PVA used in adhesives, coatings, and detergents. It provides good film formation and adhesion properties.

• Celvol 805: Another variant from Celanese, Celvol 805, is a high-performance PVA grade used in applications such as emulsion polymerization and textile processing.

• BP-05: BP-05, produced by Nippon Gohsei, is a versatile PVA grade widely used in paper coatings, emulsions, and packaging films due to its excellent water resistance and binding properties.

Polyvinyl alcohol, with variants like PVA 088-07 and PVA 0888, plays a significant role in numerous industries. The superior properties of these grades make them ideal for various applications, while reliable manufacturers like Kuraray, Sinopec, and Mowiol provide high-quality PVA products. Exploring the potential of PVA opens up a world of possibilities for creating innovative solutions in diverse industries.

Polyvinyl Alcohol (PVA) fiber is a remarkable material with a wide range of applications. Also known as Water Soluble PVA fiber, it offers unique properties that make it indispensable in various industries. Whether it’s for cold water or hot water solubility, Sinopec and Wanwei, leading PVA fiber manufacturers, are trusted suppliers delivering high-quality products.

Understanding PVA Fiber

PVA fiber is a synthetic polymer fiber made from polyvinyl alcohol resins. It possesses excellent water solubility, making it an ideal choice for applications where biodegradability and eco-friendliness are crucial. The fiber dissolves completely in water, leaving no residue behind. This property makes PVA fiber an attractive option for industries seeking sustainable solutions.

Applications of PVA Fiber

Construction Industry

PVA fiber is widely used in the construction industry to enhance the properties of concrete. By adding PVA fiber to the concrete mix, it improves its tensile strength, crack resistance, and durability. The fibers disperse uniformly within the concrete matrix, reinforcing it and preventing the formation of cracks. This ensures the longevity of structures, making PVA fiber an essential component in construction projects.

Textile Industry

In the textile industry, PVA fiber finds application in the production of water-soluble films, embroidery backing, and temporary spacers. Its excellent water solubility allows for easy removal during garment washing or embroidery processes, making it a convenient choice for manufacturers.

Pharmaceutical Industry

PVA fiber’s biodegradability and non-toxic nature make it suitable for pharmaceutical applications. It is widely used for drug encapsulation and controlled drug release systems. The fiber acts as a protective carrier, ensuring the drugs are not released too quickly, thus enabling targeted and controlled medication delivery.

Agricultural Industry

PVA fiber can also be employed in agriculture for seed coating and controlled-release fertilizers. By coating seeds with PVA fiber, it enhances germination rates, protects seeds from environmental factors, and promotes healthy plant growth. Moreover, PVA fiber can be used to encapsulate fertilizers and control the release of nutrients, providing plants with a steady supply of nourishment.

Choosing the Right PVA Fiber Supplier

When it comes to selecting a PVA fiber supplier, it’s crucial to partner with reputable manufacturers like Sinopec and Wanwei. These well-established companies ensure consistent quality, adhere to industry standards, and provide reliable customer support. Whether you require cold water soluble or hot water soluble PVA fiber, collaborating with trusted suppliers guarantees the highest caliber product.

In conclusion, PVA fiber offers unparalleled benefits across a wide range of industries. Its exceptional water solubility, biodegradability, and versatility make it a sought-after material. Whether you’re in construction, textiles, pharmaceuticals, or agriculture, PVA fiber is a smart and eco-friendly choice. Trust Sinopec and Wanwei, leading PVA fiber manufacturers, to deliver the finest quality fiber for all your water soluble needs.

Polyvinyl Alcohol (PVA) is a versatile polymer that finds a wide range of applications across various industries. From adhesive formulations to the textile industry, PVA offers excellent film-forming properties, adhesion, and solubility. The PVA 098-60G and PVA 2499 grades are specifically designed to meet the diverse needs of PVA enthusiasts. In this article, we will explore some valuable tips and tricks to enhance your PVA projects using these grades.

1. Proper Storage and Handling

Storing your PVA 098-60G and PVA 2499 properly is crucial to maintain their quality and functionality. Store the material in a cool and dry place, away from direct sunlight and moisture. Seal the containers tightly after each use to prevent moisture absorption and maintain the polymer’s viscosity.

2. Gradual Rehydration

When working with PVA powders such as PVA 098-60G, it is recommended to rehydrate the polymer gradually. Add the powder to water slowly while stirring continuously to prevent clumping and ensure proper dissolution. This method helps in achieving a smooth and uniform solution.

3. Enhancing Viscosity

If you require higher viscosity in your PVA solution, you can increase the concentration of the polymer. This will result in a thicker solution, ideal for applications such as paper coatings and adhesives. Experiment with different concentrations to find the desired viscosity for your project.

4. Controlling Dry Time

To control the dry time of PVA-based coatings or films, you can adjust the humidity and temperature of the environment. Higher humidity levels result in slower drying times, while lower humidity speeds up the drying process. Additionally, increasing the temperature accelerates the evaporation of water, leading to faster drying.

5. Compatibility Testing

Before using PVA 098-60G or PVA 2499 for your specific application, it is advisable to conduct compatibility testing. Test the PVA solution or film with other materials, substrates, or chemicals involved in your project. This helps ensure proper adhesion and compatibility between different components.

6. Cleaning and Removal

When using PVA as an adhesive or coating, cleaning up can be challenging. If you need to remove excess or dried PVA, you can try soaking the affected area in warm water. This helps in loosening the polymer, making it easier to remove. For stubborn residue, gentle scrubbing or the use of solvents may be necessary.

7. Experiment and Innovate

Polyvinyl Alcohol offers endless possibilities for innovation in various industries. Don’t be afraid to experiment with different concentrations, additives, or application methods. Test the limits of PVA 098-60G and PVA 2499 to discover new ways to enhance your projects and achieve exceptional results.

Remember, practice makes perfect. As you gain more experience working with PVA, you will develop your own set of tips and tricks. PVA 098-60G and PVA 2499 are excellent choices for PVA enthusiasts seeking reliable and versatile grades that deliver outstanding performance.

Now it’s time to unleash your creativity and take your PVA projects to new heights!

Polyvinyl Alcohol, commonly known as PVOH, is a versatile polymer widely used in various industries. Its unique properties make it suitable for applications ranging from adhesives and coatings to textiles and packaging. In this article, we will compare and contrast different PVOH manufacturers and their products, including PVA 098-20, PVA 1599, KURARAY POVAL, Sinopec PVA, Poval 25-100, Mowiol 20-98, BF-17, BF-14, and Elvanol 80-18.

1. Polyvinyl Alcohol 1599

Polyvinyl Alcohol 1599 is a high-quality PVOH product widely recognized for its excellent film-forming properties and water solubility. It offers exceptional adhesion, making it suitable for applications such as paper coatings, textiles, and detergents. Its film-forming characteristics make it beneficial for thin film applications, providing an excellent barrier against oxygen and moisture.

2. PVA 098-20

PVA 098-20 is another noteworthy PVOH product known for its outstanding tensile strength and flexibility. Its high molecular weight enables it to form strong, durable films, making it suitable for applications that require excellent mechanical properties. It finds utilization in the production of adhesives, paints, and textiles.

3. KURARAY POVAL

KURARAY POVAL is a renowned PVOH manufacturer offering a wide range of PVOH products suitable for various applications. Their product portfolio includes grades with varying degrees of hydrolysis, molecular weight, and viscosity. KURARAY POVAL products are widely used in industries such as packaging, paper coatings, and textiles, providing exceptional performance and reliability.

4. Sinopec PVA

Sinopec PVA is a leading PVOH manufacturer known for producing high-quality and reliable PVOH products. Their offerings cater to industries such as adhesives, films, and construction materials. Sinopec PVA products are well-regarded for their superior water solubility, adhesion, and film-forming properties.

5. Poval 25-100

Poval 25-100 is a PVOH product with excellent tensile strength and flexibility. It is widely used in industries such as textiles, paper coatings, and packaging. Its unique characteristics make it suitable for applications that require strong adhesion and durability.

6. Mowiol 20-98

Mowiol 20-98 is a premium-grade PVOH product recognized for its exceptional film-forming properties, high tensile strength, and good water solubility. It finds applications in adhesive formulations, paper coatings, and emulsion polymerization processes, offering excellent performance and reliability.

7. BF-17 and BF-14

BF-17 and BF-14 are PVOH products known for their excellent cold water solubility and film-forming capabilities. They find usage in various industries, including textiles, adhesives, and coatings. These PVOH grades are often preferred for their fast-dissolving properties and smooth film appearance.

8. Elvanol 80-18

Elvanol 80-18 is a high-performance PVOH product highly regarded for its exceptional film strength and stability. It finds extensive use in applications such as films, adhesives, and paper coatings. Elvanol 80-18 offers excellent chemical resistance and adhesion, making it a preferred choice in demanding environments.

In conclusion, while there are several PVOH manufacturers offering a variety of products, each with its unique properties, the choice of the most suitable product depends on the specific application requirements. Whether you are looking for excellent film-forming capabilities, water solubility, adhesion, or flexibility, there is a PVOH product available to meet your needs.

The world of VAE Emulsion (Vinyl Acetate–ethylene Copolymer Emulsion) is a captivating blend of science and creativity, presenting endless possibilities for enthusiasts. Within this realm, one emulsion stands out among the rest: VAE Emulsion CW40-757. Possessing a plethora of unique features and offering numerous benefits, this emulsion is a game-changer for professionals and hobbyists alike.

1. Unrivaled Flexibility

Flexibility is one of the key factors that sets VAE Emulsion CW40-757 apart. Its remarkable elasticity allows it to adapt to a wide range of applications. Whether you’re working on a commercial project or engaged in an artistic endeavor, this emulsion provides unrivaled flexibility, ensuring that your creation remains intact, even in challenging conditions.

2. Enhanced Adhesion

When it comes to adhesion, VAE Emulsion CW40-757 exceeds expectations. Its strong binding qualities allow for excellent adhesion to various surfaces, including wood, concrete, and metals. Whether you’re coating furniture, creating artwork, or working on construction projects, this emulsion ensures a long-lasting bond, giving you peace of mind and exceptional results.

3. Superior Water Resistance

VAE Emulsion CW40-757 boasts impressive water resistance. It forms a protective barrier on surfaces, shielding them from moisture damage and extending their lifespan. Whether you’re involved in outdoor projects or require water-resistant coatings for interior applications, this emulsion is designed to withstand the test of time, ensuring your creations withstand even the harshest environments.

4. Excellent Versatility

One of the greatest advantages of VAE Emulsion CW40-757 is its remarkable versatility. Compatible with a wide range of pigments and additives, this emulsion opens up a world of color possibilities. Whether you prefer vibrant, bold hues or subtle, muted tones, this emulsion allows you to achieve stunning results, tailored to your unique vision.

5. Low VOC (Volatile Organic Compound) Content

VAE Emulsion CW40-757 prioritizes environmental responsibility as it boasts a low VOC content. By using this emulsion, you contribute to a healthier and greener atmosphere. It meets stringent environmental regulations, making it an ideal choice for eco-conscious individuals and companies striving to reduce their carbon footprint.

6. Ease of Application

Simplicity is key, and VAE Emulsion CW40-757 acknowledges that. It offers ease of application, ensuring a smooth and hassle-free experience. Whether you’re an experienced professional or a beginner exploring the world of VAE emulsions, you’ll appreciate the user-friendly nature of this product, allowing you to focus on your craft rather than wrestling with complicated application techniques.

In conclusion, VAE Emulsion CW40-757 stands as an exceptional choice for enthusiasts seeking superior performance and unparalleled benefits. With its flexibility, enhanced adhesion, water resistance, versatility, low VOC content, and ease of application, this emulsion empowers you to bring your creative visions to life with confidence and finesse. So, embrace the power of VAE Emulsion CW40-757 and unlock new horizons in your artistic and professional endeavors.

If you’re new to the world of PVC materials and looking to learn more about PVOH 725 PVC Grade, you’ve come to the right place. In this step-by-step guide, we’ll walk you through the basics of using PVOH 725 PVC Grade, ensuring that you are well-equipped to handle this material with confidence.

Step 1: Understanding PVOH 725 PVC Grade

PVOH 725 PVC Grade is a type of polyvinyl alcohol (PVOH) specifically designed for use in the PVC industry. It is known for its excellent film-forming properties, high tensile strength, and exceptional clarity. Before you start working with it, it’s important to familiarize yourself with its properties and understand its specific applications.

Step 2: Preparing Your Workspace

Before handling any materials, make sure your workspace is clean and well-organized. Clear away any unnecessary clutter and ensure that you have all the necessary tools and equipment readily available. This will help you work efficiently and minimize the risk of any accidents or mishaps.

Step 3: Safety First

Always prioritize your safety when working with any materials. Ensure that you are wearing appropriate personal protective equipment (PPE), including safety glasses, gloves, and a dust mask. It’s also important to work in a well-ventilated area to avoid inhaling any fumes or dust particles.

Step 4: Proper Measurements

Accurate measurements are crucial when working with PVOH 725 PVC Grade. Use a precise measuring scale or weigh the required amount to avoid any inconsistencies in your final product. Remember to take into account any specific ratios or guidelines provided by the manufacturer.

Step 5: Mixing and Handling

When handling PVOH 725 PVC Grade, it’s essential to follow the manufacturer’s instructions. This usually involves gradually adding the material to the desired medium or solvent while stirring continuously to ensure proper dispersion. Take care not to introduce any contaminants into the mixture, as this can affect the quality of your end product.

Step 6: Application Techniques

Depending on your specific project, there are various application techniques you can use with PVOH 725 PVC Grade. This versatile material can be applied through brushing, spraying, or dipping methods. Experiment with different techniques to achieve the desired results, and always consult the manufacturer’s guidelines for best practices.

Step 7: Curing and Drying

Once you have successfully applied PVOH 725 PVC Grade, it’s time to allow it to cure and dry. The curing time may vary depending on factors such as temperature and humidity. Follow the recommended curing time specified by the manufacturer to ensure optimal results.

Step 8: Finishing Touches

Once the material has fully cured and dried, you can proceed with any necessary finishing touches. This may involve sanding, polishing, or applying a protective coating depending on the desired outcome. Take your time and pay attention to detail to achieve the best possible finish.

Step 9: Maintenance and Storage

Proper maintenance and storage of PVOH 725 PVC Grade can extend its lifespan and ensure its quality remains intact. Store the material in a cool, dry place away from direct sunlight. Avoid exposing it to extreme temperatures or moisture, as this can compromise its properties.

Congratulations! You have now completed the beginner’s guide to using PVOH 725 PVC Grade. By following these step-by-step instructions, you are well on your way to mastering this versatile material. Remember to always refer to the manufacturer’s guidelines for specific details and safety precautions. Happy experimenting and creating!

Sci Rep. 2017 Mar 31:7:45633.  doi: 10.1038/srep45633.

Precise Photodynamic Therapy of Cancer via Subcellular Dynamic Tracing of Dual-loaded Upconversion Nanophotosensitizers

Yulei Chang 1, Xiaodan Li 1 2, Li Zhang 1 2, Lu Xia 1, Xiaomin Liu 1, Cuixia Li 1, Youlin Zhang 1, Langping Tu 1 3, Bin Xue 1 3, Huiying Zhao 2, Hong Zhang 3, Xianggui Kong 1

Abstract

Recent advances in upconversion nanophotosensitizers (UCNPs-PS) excited by near-infrared (NIR) light have led to substantial progress in improving photodynamic therapy (PDT) of cancer.  For a successful PDT, subcellular organelles are promising therapeutic targets for reaching a satisfactory efficacy.  It is of vital importance for these nanophotosensitizers to reach specifically the organelles and to perform PDT with precise time control.  To do so, we have in this work traced the dynamic subcellular distribution, especially in organelles such as lysosomes and mitochondria, of the poly(allylamine)-modified and dual-loaded nanophotosensitizers.  The apoptosis of the cancer cells induced by PDT with the dependence of the distribution status of the nanophotosensitizers in organelles was obtained, which has provided an in-depth picture of intracellular trafficking of organelle-targeted nanophotosensitizers.  Our results shall facilitate the improvement of nanotechnology assisted photodynamic therapy of cancers.
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Abbreviation: mPEG-SC
Name: Methoxypoly(ethylene glycol) succinimidyl carbonate

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